A method for tailoring the information content of a software process model

The framework is defined for a general method for selecting a necessary and sufficient subset of a general software life cycle's information products, to support new software development process. Procedures for characterizing problem domains in general and mapping to a tailored set of life cycle processes and products is presented. An overview of the method is shown using the following steps: (1) During the problem concept definition phase, perform standardized interviews and dialogs between developer and user, and between user and customer; (2) Generate a quality needs profile of the software to be developed, based on information gathered in step 1; (3) Translate the quality needs profile into a profile of quality criteria that must be met by the software to satisfy the quality needs; (4) Map the quality criteria to set of accepted processes and products for achieving each criterion; (5) Select the information products which match or support the accepted processes and product of step 4; and (6) Select the design methodology which produces the information products selected in step 5

A method for tailoring the information content of a software process model

The framework is defined for a general method for selecting a necessary and sufficient subset of a general software life cycle's information products, to support new software development process. Procedures for characterizing problem domains in general and mapping to a tailored set of life cycle processes and products is presented. An overview of the method is shown using the following steps: (1) During the problem concept definition phase, perform standardized interviews and dialogs between developer and user, and between user and customer; (2) Generate a quality needs profile of the software to be developed, based on information gathered in step 1; (3) Translate the quality needs profile into a profile of quality criteria that must be met by the software to satisfy the quality needs; (4) Map the quality criteria to a set of accepted processes and products for achieving each criterion; (5) select the information products which match or support the accepted processes and product of step 4; and (6) Select the design methodology which produces the information products selected in step 5

Evaluation of the Trajectory Operations Applications Software Task (TOAST). Volume 2: Interview transcripts

The Trajectory Operations Applications Software Task (TOAST) is a software development project whose purpose is to provide trajectory operation pre-mission and real-time support for the Space Shuttle. The purpose of the evaluation was to evaluate TOAST as an Application Manager - to assess current and planned capabilities, compare capabilities to commercially-available off the shelf (COTS) software, and analyze requirements of MCC and Flight Analysis Design System (FADS) for TOAST implementation. As a major part of the data gathering for the evaluation, interviews were conducted with NASA and contractor personnel. Real-time and flight design users, orbit navigation users, the TOAST developers, and management were interviewed. Code reviews and demonstrations were also held. Each of these interviews was videotaped and transcribed as appropriate. Transcripts were edited and are presented chronologically

Refiner Peroxide Bleaching

Refiner peroxide bleaching trials were carried out at the Abitibi-Price Research pilot plant using a Sunds-Defibrator CD300 pilot-scale refiner. Results show that, at the pilot scale, blowline addition of bleach liquor gives better brightness gains than addition in the refining zone. Using this technique, brightness gains equivalent to tower bleaching can be obtained when the bleaching parameters are properly controlled. The most important factors were post-refiner retention time and temperature, and the alkali charge in the bleach liquor. These three factors were shown to be highly interdependent. Refining pressure (temperature) was shown to have little effect on brightness gain in this system but did effect both the bleached and unbleached brightness of the TMP. As in tower bleaching, it was found that chelation of metal ions is essential if maximum bleaching efficiency is to be achieved. Refiner blowline bleaching had no effect on pulp strength other than that expected from peroxide bleaching under more standard conditions. A mathematical model of peroxide bleaching was also developed with the intended use of calculating the required bleaching parameters for a mill system. Other experiments showed that refiner dithionite (hydrosulphite) bleaching holds promise but that the best overall system might be refiner blowline peroxide bleaching followed by dithionite bleaching in a second stage. Computer modelling of this two-stage system and a cost analysis of the results showed that as much as a 30% reduction of chemical cost can be achieved if two-stage bleaching is used instead of peroxide bleaching alone

Great Bay Coast Watch: A Citizen Water Monitoring Program Volunteer Water Quality Monitoring Manual, 2004

The Great Bay Coast Watch is citizen volunteers, working within the UNH Cooperative Extension/NH Sea Grant Program, protecting the long-term health and natural resources of New Hampshire’s coastal waters and estuarine systems through monitoring and education projects. The purpose of this document is to present step-by-step instructions for conducting water quality testing in support of the Great Bay Coast Watch (GBCW)

Scaffolding Knowledge Management in ePortfolios

A key challenge in Higher Education is how to develop learning and assessment opportunities that will assist students in constructing and sharing knowledge through absorbing, embedding and reflecting on their learning experiences. This paper explores the role of ePortfolios in knowledge management within the context of education. Portfolios provide students with the opportunity to document their learning journey and have become established artefacts in evidence-based practice. EPortfolios support a range of multimedia which can be included to enrich the portfolio and embrace social technologies. This paper examines a range of applications of ePortfolios in different UK Higher Education Institutions, across disciplines including education, business and computing. Differences in the purpose, use, style and assessment of ePortfolios are considered and a taxonomy of distinct approaches to structuring ePortfolios is developed. The taxonomy is then analysed in terms of the extent to which the different applications of ePortfolios provide opportunities to support the development and assessment of student knowledge. Specifically, the role of structuring knowledge within ePortfolios is considered. The initial findings demonstrate that ePortfolios harness a student's skill in social networking, capturing their imagination and promoting engagement in knowledge related activities. The role of the artefact in stimulating and facilitating knowledge is reviewed using the theory of the task-artefact cycle. The experience of using ePortfolios in knowledge management is then compared against previous work which has explored the use of blogs as tools of knowledge construction to encourage reflection. The paper concludes by proposing recommendations for the development of learning opportunities which embrace the knowledge management capabilities of ePortfolios and considers the potential broader role for ePortfolios in knowledge management

Global Diffusion of the Internet XV: Web 2.0 Technologies, Principles, and Applications: A Conceptual Framework from Technology Push and Demand Pull Perspective

Web 2.0, the current Internet evolution, can be described by several key features of an expanded Web that is more interactive; allows easy social interactions through participation and collaboration from a variety of human sectors; responds more immediately to users\u27 queries and needs; is easier to search; and provides a faster, smoother, realistic and engaging user search capability, often with automatic updates to users. The purpose of this study is three-fold. First, the primary goal is to propose a conceptual Web 2.0 framework that provides better understanding of the Web 2.0 concept by classifying current key components in a holistic manner. Second, using several selective key components from the conceptual framework, this study conducts case analyses of Web 2.0 applications to discuss how they have adopted the selective key features (i.e., participation, collaboration, rich user experience, social networking, semantics, and interactivity responsiveness) of the conceptual Web 2.0 framework. Finally, the study provides insightful discussion of some challenges and opportunities provided by Web 2.0 to education, business, and social life

Oxidative Stress in Oocytes during Midprophase Induces Premature Loss of Cohesion and Chromosome Segregation Errors

In humans, errors in meiotic chromosome segregation that produce aneuploid gametes increase dramatically as women age, a phenomenon termed the maternal age effect. During meiosis, cohesion between sister chromatids keeps recombinant homologs physically attached and premature loss of cohesion can lead to missegregation of homologs during meiosis I. A growing body of evidence suggests that meiotic cohesion deteriorates as oocytes age and contributes to the maternal age effect. One hallmark of aging cells is an increase in oxidative damage caused by reactive oxygen species (ROS). Therefore, increased oxidative damage in older oocytes may be one of the factors that leads to premature loss of cohesion and segregation errors. To test this hypothesis, we used an RNAi strategy to induce oxidative stress in Drosophila oocytes and measured the fidelity of chromosome segregation during meiosis. Knockdown of either the cytoplasmic or mitochondrial ROS scavenger superoxide dismutase (SOD) caused a significant increase in segregation errors, and heterozygosity for an smc1 deletion enhanced this phenotype. FISH analysis indicated that SOD knockdown moderately increased the percentage of oocytes with arm cohesion defects. Consistent with premature loss of arm cohesion and destabilization of chiasmata, the frequency at which recombinant homologs missegregate during meiosis I is significantly greater in SOD knockdown oocytes than in controls. Together these results provide an in vivo demonstration that oxidative stress during meiotic prophase induces chromosome segregation errors and support the model that accelerated loss of cohesion in aging human oocytes is caused, at least in part, by oxidative damage

Shared care in mental illness: A rapid review to inform implementation

<p>Abstract</p> <p>Background</p> <p>While integrated primary healthcare for the management of depression has been well researched, appropriate models of primary care for people with severe and persistent psychotic disorders are poorly understood. In 2010 the NSW (Australia) Health Department commissioned a review of the evidence on "shared care" models of ambulatory mental health services. This focussed on critical factors in the implementation of these models in clinical practice, with a view to providing policy direction. The review excluded evidence about dementia, substance use and personality disorders.</p> <p>Methods</p> <p>A rapid review involving a search for systematic reviews on The Cochrane Database of Systematic Reviews and Database of Abstracts of Reviews of Effects (DARE). This was followed by a search for papers published since these systematic reviews on Medline and supplemented by limited iterative searching from reference lists.</p> <p>Results</p> <p>Shared care trials report improved mental and physical health outcomes in some clinical settings with improved social function, self management skills, service acceptability and reduced hospitalisation. Other benefits include improved access to specialist care, better engagement with and acceptability of mental health services. Limited economic evaluation shows significant set up costs, reduced patient costs and service savings often realised by other providers. Nevertheless these findings are not evident across all clinical groups. Gains require substantial cross-organisational commitment, carefully designed and consistently delivered interventions, with attention to staff selection, training and supervision. Effective models incorporated linkages across various service levels, clinical monitoring within agreed treatment protocols, improved continuity and comprehensiveness of services.</p> <p>Conclusions</p> <p>"Shared Care" models of mental health service delivery require attention to multiple levels (from organisational to individual clinicians), and complex service re-design. Re-evaluation of the roles of specialist mental health staff is a critical requirement. As expected, no one model of "shared" care fits diverse clinical groups. On the basis of the available evidence, we recommended a local trial that examined the process of implementation of core principles of shared care within primary care and specialist mental health clinical services.</p

\u3ci\u3eIn Vitro\u3c/i\u3e Gene Regulatory Networks Predict In Vivo Function of Liver

Background: Evolution of toxicity testing is predicated upon using in vitro cell based systems to rapidly screen and predict how a chemical might cause toxicity to an organ in vivo. However, the degree to which we can extend in vitro results to in vivo activity and possible mechanisms of action remains to be fully addressed. Results: Here we use the nitroaromatic 2,4,6-trinitrotoluene (TNT) as a model chemical to compare and determine how we might extrapolate from in vitro data to in vivo effects. We found 341 transcripts differentially expressed in common among in vitro and in vivo assays in response to TNT. The major functional term corresponding to these transcripts was cell cycle. Similarly modulated common pathways were identified between in vitro and in vivo. Furthermore, we uncovered the conserved common transcriptional gene regulatory networks between in vitro and in vivo cellular liver systems that responded to TNT exposure, which mainly contain 2 subnetwork modules: PTTG1 and PIR centered networks. Interestingly, all 7 genes in the PTTG1 module were involved in cell cycle and downregulated by TNT both in vitro and in vivo. Conclusions: The results of our investigation of TNT effects on gene expression in liver suggest that gene regulatory networks obtained from an in vitro system can predict in vivo function and mechanisms. Inhibiting PTTG1 and its targeted cell cyle related genes could be key machanism for TNT induced liver toxicity